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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HUWE1
All Species:
13.64
Human Site:
S3590
Identified Species:
37.5
UniProt:
Q7Z6Z7
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z6Z7
NP_113584.3
4374
481891
S3590
L
S
V
E
V
L
T
S
H
S
C
S
E
E
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088987
4374
481661
S3590
L
S
V
E
V
L
T
S
H
S
C
S
E
E
G
Dog
Lupus familis
XP_538052
4375
482124
S3591
L
S
V
E
V
L
T
S
H
S
C
S
E
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q7TMY8
4377
482644
S3591
L
S
V
E
V
L
T
S
H
S
C
S
E
E
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923899
4360
479137
I3588
G
L
E
D
A
A
N
I
L
L
Q
L
S
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573059
5146
556842
H4328
L
V
I
E
V
L
T
H
Q
C
G
T
T
E
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500284
4177
465393
V3431
L
A
E
K
L
E
F
V
I
Q
V
M
T
T
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GY23
3681
404981
E2972
Y
T
A
A
S
R
I
E
G
W
S
P
S
S
G
Baker's Yeast
Sacchar. cerevisiae
Q03280
3268
374166
D2559
E
I
L
Q
S
L
I
D
A
D
S
R
L
K
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
98.7
N.A.
97.7
N.A.
N.A.
N.A.
N.A.
N.A.
81.6
N.A.
33.7
N.A.
26.2
N.A.
Protein Similarity:
100
N.A.
99.7
99.1
N.A.
98.6
N.A.
N.A.
N.A.
N.A.
N.A.
88.4
N.A.
48.4
N.A.
44.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
46.6
N.A.
13.3
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
60
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.1
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
12
12
12
0
0
12
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
12
45
0
0
0
0
% C
% Asp:
0
0
0
12
0
0
0
12
0
12
0
0
0
0
0
% D
% Glu:
12
0
23
56
0
12
0
12
0
0
0
0
45
56
0
% E
% Phe:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% F
% Gly:
12
0
0
0
0
0
0
0
12
0
12
0
0
0
89
% G
% His:
0
0
0
0
0
0
0
12
45
0
0
0
0
0
0
% H
% Ile:
0
12
12
0
0
0
23
12
12
0
0
0
0
0
0
% I
% Lys:
0
0
0
12
0
0
0
0
0
0
0
0
0
12
0
% K
% Leu:
67
12
12
0
12
67
0
0
12
12
0
12
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% M
% Asn:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% P
% Gln:
0
0
0
12
0
0
0
0
12
12
12
0
0
0
0
% Q
% Arg:
0
0
0
0
0
12
0
0
0
0
0
12
0
12
0
% R
% Ser:
0
45
0
0
23
0
0
45
0
45
23
45
23
12
0
% S
% Thr:
0
12
0
0
0
0
56
0
0
0
0
12
23
12
0
% T
% Val:
0
12
45
0
56
0
0
12
0
0
12
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% W
% Tyr:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _